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San Marcos ( SAN MAR-kohs; Spanish for “St. Mark”) is a city in the North County region of San Diego County, California. As of the 2020 census, the city’s population was 94,833. It is the site of California State University San Marcos. The city is bordered by Escondido to the east, Encinitas to the southwest, Carlsbad to the west, and Vista to the northwest. Lake San Marcos is an enclave, or county island, in the southwestern part of the city, within San Marcos’ sphere of influence but technically an unincorporated community.

According to historical legends, the San Luis Rey Mission flocks were robbed by a small band of Native Americans in the late 18th century. Fleeing the Spanish troops, the Native Americans escaped to the hills. While pursuing the Native Americans, in 1797 the Spaniards came upon a fertile valley, which was named Los Vallecitos de San Marcos (Little Valleys of Saint Mark) to honor the day of discovery: April 25, St. Mark’s Day. On April 22, 1840, Governor Juan B. Alvarado granted Rancho Vallecitos de San Marcos to his relative, Jose María Alvarado. Jose Alvarado was killed at the Pauma Massacre in 1846, and the land was left to his wife; she then sold the land to Lorenzo Soto. In the late 1850s, Soto sold part of his land to Cave Couts, and his family was soon raising livestock. Although Cave Couts owned the land, Major Gustavus French Merriam from Topeka, Kansas, made the first permanent settlement. Merriam homesteaded 160 acres (0.65 km) in the north Twin Oaks Valley and began wine and honey production.