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Medford is a city 6.7 miles (10.8 km) northwest of downtown Boston on the Mystic River in Middlesex County, Massachusetts, United States. At the time of the 2020 U.S. Census, Medford’s population was 59,659. It is home to Tufts University, which has its campus along the Medford and Somerville border.

Native Americans inhabited the area that would become Medford for thousands of years prior to European colonization of the Americas. At the time of European contact and exploration, Medford was the winter home of the Naumkeag people, who farmed corn and created fishing weirs at multiple sites along the Mystic River. Naumkeag sachem Nanepashemet was killed and buried at his fortification in present-day Medford during a war with the Tarrantines in 1619. The contact period introduced a number of European infectious diseases which would decimate native populations in virgin soil epidemics, including a smallpox epidemic which in 1633 killed Nanepashemet’s sons, sachems Montowompate and Wonohaquaham. Sagamore Park in West Medford is a native burial site from the contact period which includes the remains of a likely sachem, either Nanepashemet or Wonohaquaham. After the 1633 epidemic, Nanepashemet’s widow, known only as the Squaw Sachem of Mistick, led the Naumkeag, and over the next two decades would deed large parts of Naumkeag territory to English settlers. In 1639, the Massachusetts General Court purchased the land that would become present day Medford, then within the boundaries of Charlestown, from the Squaw Sachem.