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Middleborough is a town in Plymouth County, Massachusetts, United States. The population was 24,245 at the 2020 census. The census-designated place of Middleborough Center corresponds to the main village and commercial center of the town. It is the second largest municipality by land area in Massachusetts and nineteenth largest in New England. Middleborough proclaims itself to be the “Cranberry Capital of the World”. Cranberry production remains a significant part of the local economy. In 2015, approximately 1,400 acres of the town were used to grow the crop, accounting for 3% of all land used to harvest cranberry bogs in the United States.

The town was first settled by Europeans in 1661 as Nemasket, later changed to Middlebury, and officially incorporated as Middleborough in 1669. The name Nemasket came from a Native American settlement along the small river that now bears the same name. Nemasket may have meant “place of fish”, due to the large amount of herring that migrate up the river each spring. There are no contemporary records that indicate the name Middlebury was taken from a place in England. The names Middlebury and Middleborough were actually derived from the city of Middelburg, Zeeland, the westernmost province of the Netherlands.^{[citation needed]} Middelburg was an international intellectual center and economic powerhouse. The English religious dissenters known as the Brownists developed their governing institutions in Middelburg before emigrating on the Mayflower, and were the earliest settlers of Middleborough.